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\n\t\t\t\t\t\t\t\u5728<\/span>\u7ec4\u7ec7\u4fee\u590d<\/span><\/strong>\u4e2d\uff1a\u4e8c\u7532\u53cc\u80cd\u4fee\u590d\u4e86\u5927\u591a\u6570\u8001\u5316\u7ec4\u7ec7\uff0c\u5176\u4e2d\u989d\u53f6\u3001\u76ae\u80a4\u3001\u809d\u810f\u3001\u80be\u810f\u3001\u80a1\u56db\u5934\u808c\u548c\u80ba\u7b49\u7ec4\u7ec7\u4fee\u590d\u6700\u4e3a\u663e\u8457\u3002<\/span>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\u4e3a\u4e86<\/span>\u91cf\u5316<\/span><\/strong>\u4e8c\u7532\u53cc\u80cd\u5f15\u8d77\u7684\u751f\u7269\u5e74\u9f84\u51cf\u7f13\uff0c\u5b9e\u9a8c\u4eba\u5458\u57fa\u4e8e<\/span>\u591a\u7ec4\u5b66\u6570\u636e<\/span><\/span><\/strong>\u5efa\u7acb\u4e86\u7334\u5b50\u8870\u8001\u65f6\u949f\u7684\u8ba1\u7b97\u6a21\u578b\u3002\u6307\u6807\u5305\u542b\uff1a<\/span>DNAmAge\uff08\u57fa\u4e8eDNA\u7532\u57fa\u5316\uff09\u3001transcriptAge\uff08\u57fa\u4e8e\u8f6c\u5f55\u7ec4\uff09\u3001proteinAge\uff08\u57fa\u4e8e\u86cb\u767d\u8d28\u7ec4\uff09\u548cmetabAge\uff08\u57fa\u4e8e\u4ee3\u8c22\u7ec4\uff09\u3002<\/span><\/strong>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\u86cb\u767d\u8d28\u7ec4\u5e74\u9f84\uff1a<\/span><\/strong>\u5e73\u5747\u9006\u8f6c6.41\u5e74\u3002<\/span>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\tDNA\u7532\u57fa\u5316\u5e74\u9f84\uff1a<\/span><\/strong>\u591a\u7ec4\u7ec7DNA\u9006\u8f6c\u6548\u679c\u4e5f\u663e\u8457\uff0c\u4f8b\u5982\u989d\u53f6\uff08-6.10\u5e74\uff09\u3001\u80ba\uff08-5.11\u5e74\uff09\u3001\u80be\u76ae\u8d28\uff08-4.90\u5e74\uff09\u3001\u809d\uff08-3.95\u5e74\uff09\u3002<\/span>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t\u8f6c\u5f55\u7ec4\u5e74\u9f84\uff1a<\/span><\/strong>13\u4e2a\u7ec4\u7ec7\u8f6c\u5f55\u5e74\u9f84\u5747\u9006\u8f6c\uff0c\u5c24\u4ee5\u8ddf\u8171\uff08-5.31\u5e74\uff09\u3001\u809d\u810f\uff08-4.14\u5e74\uff09\u3001\u652f\u6c14\u7ba1\uff08-3.71\u5e74\uff09\u6548\u679c\u6700\u663e\u8457\u3002<\/span>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t\u4ee3\u8c22\u7ec4\u5e74\u9f84\uff1a<\/span><\/strong>\u5e73\u5747\u9006\u8f6c2.30\u5e74\u3002<\/span>\n\t\t\t\t\t\t<\/p>\n\t\t\t\t\t\t

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\n\t\t[1] Yang, Y., Lu, X., Liu, N., et al. (2024). Metformin decelerates aging clock in male monkeys. Cell 187(22), 6358-6378.e29. <\/span>\n\t<\/p>\n\t

\n\t\thttps:\/\/doi.org\/10.1016\/j.cell.2024.08.021<\/span>\n\t<\/p>\n\t

\n\t\t[2] Bailey, C.J. (2017). Metformin: historical overview. Diabetologia 60(9), 1566-1576. <\/span>\n\t<\/p>\n\t

\n\t\thttps:\/\/doi.org\/10.1007\/s00125-017-4318-z<\/span>\n\t<\/p>\n\t

\n\t\t[3] SterneJ(1957)Du nouveau dans les antidiab\u00e9tiques.La NN dimethylamine guanyl guanidine (N.N.D.G.) Maroc Med 36:1295\u20131296 [article in French]<\/span>\n\t<\/p>\n\t

\n\t\t[4] Fern\u00e1ndez-Garc\u00eda,J.C.,Barrios-Rodr\u00edguez,R., Asenjo-Plaza, M., et al. (2022). Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial. Metabolism 136, 155290. <\/span>\n\t<\/p>\n\t

\n\t\thttps:\/\/doi.org\/10.1016\/j.metabol.2022.155290<\/span>\n\t<\/p>\n\t

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